All Psychotic Roads Lead to Increased Dopamine D2High Receptors: A Perspective
نویسنده
چکیده
Introduction This neuroscience perspective on translational research on psychosis summarizes recent data showing that a common feature of the many animal models of psychosis is dopamine supersensitivity associated with an elevation of dopamine D2High receptors. This finding is an impetus to devising a method for measuring D2High in individuals in various stages of psychosis. All Psychotic Roads Lead to Increased Dopamine D2High Receptors: A Perspective
منابع مشابه
Dopamine supersensitivity correlates with D2High states, implying many paths to psychosis.
Dopamine supersensitivity occurs in schizophrenia and other psychoses, and after hippocampal lesions, antipsychotics, ethanol, amphetamine, phencyclidine, gene knockouts of Dbh (dopamine beta-hydroxylase), Drd4 receptors, Gprk6 (G protein-coupled receptor kinase 6), Comt (catechol-O-methyltransferase), or Th-/-, DbhTh/+ (tyrosine hydroxylase), and in rats born by Cesarean-section. The functiona...
متن کاملIs schizophrenia a dopamine supersensitivity psychotic reaction?
Adolf Meyer (1866-1950) did not see schizophrenia as a discrete disorder with a specific etiology but, rather, as a reaction to a wide variety of biopsychosocial factors. He may have been right. Today, we have evidence that gene mutations, brain injury, drug use (cocaine, amphetamine, marijuana, phencyclidine, and steroids), prenatal infection and malnutrition, social isolation and marginalizat...
متن کاملCannabidiol is a partial agonist at dopamine D2High receptors, predicting its antipsychotic clinical dose
Although all current antipsychotics act by interfering with the action of dopamine at dopamine D2 receptors, two recent reports showed that 800 to 1000 mg of cannabidiol per day alleviated the signs and symptoms of schizophrenia, although cannabidiol is not known to act on dopamine receptors. Because these recent clinical findings may indicate an important exception to the general rule that all...
متن کاملAffinity States of Striatal Dopamine D2 Receptors in Antipsychotic-Free Patients with Schizophrenia
Background Dopamine D2 receptors are reported to have high-affinity (D2High) and low-affinity (D2Low) states. Although an increased proportion of D2High has been demonstrated in animal models of schizophrenia, few clinical studies have investigated this alteration of D2High in schizophrenia in vivo. Methods Eleven patients with schizophrenia, including 10 antipsychotic-naive and 1 antipsychot...
متن کاملTargeting the dopamine D2 receptor in schizophrenia.
After a 12-year search for the antipsychotic receptor, the binding site was discovered and labelled by [3H]haloperidol in 1975. Of the various neurotransmitters, dopamine was the most potent in inhibiting the binding of [3H]haloperidol, indicating that the antipsychotic receptor was a dopamine receptor, now named the dopamine D2 receptor, a major targeting site in schizophrenia. All antipsychot...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2008